Nylon syringe filters are highly recommended in pharmaceutical laboratory analysis due to their hydrophilic properties. These syringe filters are recommended for applications that require low extractability. The following are important steps to help you choose the correct type of nylon membrane syringe filter.
Step 1-Match the Application to the Aperture
In any application, you need to first determine the particle size that needs to be retained or filtered. The nylon membrane retains all particles equal to or larger than its designated pore size. The 0.22µm pore filter membrane can be used for routine laboratory disinfection of samples. The solvent can be pre-filtered and clarified using a 0.45 µm nylon filter membrane.
Step 2-Choose the best Matching Housing Material and Membrane for your Application
The nylon membrane of the syringe filter should be compatible with the chemical characteristics of the sample. The nylon membrane should be compatible with various water-based and organic solvents. The membrane should also have high resistance to HPLC solvents and chemicals.
The filter housing material should also be compatible with the chemical characteristics of the sample. You need to look for polypropylene housing material because it has good resistance to many solvents. For example, it is recommended to use polypropylene for solvents such as weak and strong acids, alcohols and aldehydes, aliphatic and aromatic amines, and alkalis. Polypropylene shell materials may also be effective in the filtration of esters, hydrocarbons and ketones.
Step 3-Select the Correct Filter Area to Achieve the Correct Flux and Optimize the Flow Rate
You need to choose a nylon syringe filter with the correct filtration area to ensure that you have enough capacity and throughput to process samples efficiently and quickly. This can be easily determined by the surface area of the membrane filter. For example, a filtration area of 4.8 square centimeters will have a flow rate of 10 to 50 milliliters.
Step 4-Choose a suitable filter design for the application
The disc filter is very suitable for use as a pressure source and as a syringe for liquid storage tanks. You need to use an HPLC certified non-sterile syringe filter with a polypropylene housing with good chemical resistance.
Step 5-Pay attention to the fluid temperature of the sample
When choosing a nylon membrane syringe filter, pay attention to the sample temperature and the highest rated temperature of the membrane filter. The reason is that increasing the temperature of the cell culture medium from 4°C to 37°C will cause the flow rate to double. Similarly, filtration at lower temperatures can increase overall production.
The above are the five important steps to choose the correct nylon membrane syringe for laboratory testing and analysis in the pharmaceutical industry.